Stem Cell Membrane–Coated Nanodrugs Target Microglia in Alzheimer’s Models
- SSCTR Exco
- Aug 10
- 1 min read
Updated: Aug 14
Published in ACS Applied Materials & Interfaces
Researchers report Gas6-engineered neural stem cell membrane–coated nanoparticles co-loading rapamycin and nicotinamide riboside that home to microglia, restore lysosomal acidification, and enhance Aβ clearance in 5xFAD mice, with favorable brain targeting and safety. The approach aims to boost delivery and reduce immune clearance for AD nanotherapy.
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