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Novartis to Acquire Regulus for $1.7B, Advancing MicroRNA Therapies

Published on Spencer Knight via LinkedIn


Novartis is acquiring Regulus Therapeutics for up to $1.7 billion to expand its position in oligonucleotide and microRNA-based therapies. The deal includes $7.00 per share in cash upfront (approximately $800M), plus a $7.00 per share contingent value right tied to FDA approval of the anti-miR-17 therapy, rGLS4326 (farbarsuren), for Autosomal Dominant Polycystic Kidney Disease (ADPKD).


This acquisition reflects a 274% premium to Regulus’ 60-day VWAP and marks a significant moment for RNA therapeutics. The deal is expected to close in the second half of 2025, pending regulatory clearance.


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