HGH‑Overexpressing Stem Cells Speed Up Burn Wound Healing via ERK Pathway

Published in Regenerative Therapy (Vol. 30, Dec 2025)

A study in Regenerative Therapy shows that adipose-derived stem cells (ADSCs) engineered to overexpress human growth hormone (HGH) significantly improve fibroblast activity and burn wound healing in rats. These HGH-ADSCs enhanced cell proliferation, migration, and collagen formation while reducing inflammation and apoptosis. Mechanistically, the therapeutic effects were dependent on ERK signaling. When blocked, the benefits were lost. The findings support HGH-ADSCs as a potent, ERK-mediated strategy for advancing regenerative burn therapies.

Read the full article in Regenerative Therapy:

👉 Human growth hormone-overexpressing adipose-derived stem cells enhance fibroblast activity and accelerate burn wound healing via ERK pathway

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